Denosyl, a nutritional supplement, is the pure and stabilized salt of S-Adenosylmethionine for veterinary use only. It has been researched in published U.S. trials in dogs and cats. Denosyl is available in three strengths: as an enteric-coated 90 mg, 225 mg, and 425 mg tablet of active S-Adenosylmethionine. Because S-Adenosylmethionine is extremely sensitive to moisture, tablets are individually sealed in specialized moisture-resistant blister packs. Denosyl has been shown to increase hepatic glutathione levels in cats and dogs. Glutathione is a potent antioxidant that protects hepatic cells from toxins and death. A study found that low liver glutathione concentrations are common in dogs and cats with decreased hepatobiliary function. Denosyl is recommended to improve hepatic glutathione levels in patients to help maintain and protect liver function. Denosyl may also be used in other areas of tissue oxidant injury and RBC fragility caused by certain toxins or drugs which are related to reduced glutathione concentrations. Denosyl, however, goes beyond increasing glutathione levels and has been shown to protect liver cells from cell death and may be useful in cell regeneration. A study has also shown that Denosyl may improve bile flow in cats. In addition to supporting liver health, Denosyl may also support brain health as S-Adenosylmethionine has been shown to function as a neuroprotective agent.
